- Posted by Okechukwu Anosike on August 3, 2009
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Behind All Scale Up Problems
Chemical rate constants are independent of scale
Physical Parameters are not
Process time
Mixing time
Power input
Mass transfer rates
Heat transfer
Phase separation
Gas desorption
Effect Of Scale-up on some key Process variables
Chemical thermodynamics – Not Affected
Phase equilibra – Not affected
Intensive properties ( density, viscosity, Cp) – Not affected
Reaction kinetics – indirectly affected by mixing, temperature/concentration gradients
Heat transfer rates - affected by HT fluid limitations and mixing
Mass transfer rates - affected by mixing, especially heterogeneous/biphasic reactions
Some Unexpected Scale Up issues
Visibility
Access
Time
Material flow
Material handling
Mixing
Heating/cooling
Environmental factors
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Category: Chemical Engineering, Plant Scale Up's
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